Computational Pharmaceutics: Application of Molecular Modeling in Drug Delivery (Advances in Pharmaceutical Technology)

Computational Pharmaceutics: Application of Molecular Modeling in Drug Delivery (Advances in Pharmaceutical Technology)

作者:Ouyang, Defang (EDT)/ Smith, Sean C. (EDT), 出版社:Wiley, 出版日期:2015-07-20

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商品條碼:9781118573990, ISBN:1118573994
分類標籤:Subjects » Books » Reference » Education » Engineering

 

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Computational Pharmaceutics: Application of Molecular Modeling in Drug Delivery (Advances in Pharmaceutical Technology)
Through 13 chapters, chemists, engineers, and other scientists from Europe, Australia, the US, and China describe the application of computational modeling to drug delivery and pharmaceutical formulation development. Topics encompass the general principles of crystal structure prediction and advances in solid form screening by the crystal energy landscape method; the physicochemical principles of cyclodextrin/drug complexation, experimental characterization, and recent advances in drug/cyclodextrin modeling; multiscale modeling for polymeric-based vehicles for drug delivery; the possible molecular structure of amorphous solid dispersions and the mechanism of physical stability of this technology; the theoretical progress of lipid membrane models, small-molecular uptake and permeation across lipid membranes, nanoparticle-membrane interaction, and the mechanism of chemical penetration enhancers; and the modeling results on the solution behavior of protein formulation. Others discuss computational modeling of inorganic nanoparticle drug delivery systems (carbon nanotubes, graphene/graphene oxide, silica, and gold nanoparticles); the structure of the nanodiamond, its surface chemistry and interactions, and nanodiamond drug delivery systems; computational approaches to the properties and interactions of layered double hydroxide/anion systems; molecular modeling to understand the role of poly(ethylene) glycol in drug delivery; the principles of synchotron radiation-based microtomography and its application to determine the particulate architecture of granules, osmotic pump tablets, and hydroxypropyl methylcellulose matrix tablets; and the principles of pharmacokinetic modeling and simulation and commercially available models for pharmaceutical scientists. Annotation ©2015 Ringgold, Inc., Portland, OR (protoview.com)
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